Bioinformatician

Exciting Medical Devices Development company seeks an experienced Bioinformatician.

About the role:

The Bioinformatician will work within the Assay Team to develop point of care molecular diagnostic assays and associated technologies. It is an opportunity for candidates with a strong background in sequence-based bioinformatics to contribute on projects leading to the development of diagnostic assays.

Duties may include:

• Work within the Assay Team to deliver molecular diagnostic product pipeline.
• Identify appropriate reference sources for sequences, for example public sources such as GISAID and NCBI databases.
• Familiar with NextGen sequencing and associated pipelines.
• Collate and annotate reference sequences across multiple microorganisms.
• Be confident using python and Jupyter Lab books as a working and application development environment along with GIT as a version control system.
• Generate, record, manipulate, analyse and present complex data to line manager, colleagues, senior management and external partners.
• Maintain records, logs and or databases of analyses for regulatory reporting purposes.
• Interrogate sequence data to design new diagnostic assays, applying assay team lead rules (eg Tm, primer length, GC ratio) to shortlist targets for experimental testing.
• Undertake in silico inclusivity and exclusivity testing and analyse homology to confirm target suitability.
• Undertake periodic in silico review of existing assay designs to confirm ongoing suitability of the assay for VOC, VUI and variants being monitored.
• Work on collaborative projects with external partners and be point of contact for bioinformatics.
• Work within the quality systems following GDP and ISO 13485 standards.

Skills and experience:

• MSc degree or equivalent in a relevant subject (ie bioinformatics, computer science or statistics).
• Relevant experience in bioinformatics with a strong knowledge of microbial genomics.
• Familiarity with sequencing data (Sanger and NGS) and standard bioinformatics tools (alignment, variant calling, assembly etc.)
• Experience in data manipulation and analysis of large genomic datasets.
• Knowledge and competence in Python, Docker, Git, Linux, MySQL or similar software development tool.
• Knowledge of nucleic acid amplification and detection chemistries.
• Ability to work to the Quality Management Systems in line with ISO13485 standards.
• Hands on experience with the manipulation and development of PCR chemistries for diagnostic tests.
• GPU programming.
• Eligible to work full time in the UK without restriction.

Apply now for more information