PhD Studentship: Functionalised amino-acid analogues for chemical proteomics

Closing Date: 29 April 2024 at 23:59 Eligibility: UK Applicants only Funding EPSRC Doctoral Training Partnership Studentship offering the award of fees, together with a tax-free maintenance grant of £19,237 per year for 3.5 years.  Training and support will also be provided. Lead Supervisor’s full name and email address Professor Michael Webb – m.e.webb@leeds.ac.uk Co-supervisor name: To be confirmed Project summary In this project, you will build on our previous work developing stable analogues of phosphohistidine (Org. Biomol. Chem. (2012)10, 4043), dehydroalanine (Chem Commun. (2015) 51 13470) and triazine-containing analogues of phenylalanine (Chem. Eur. J (2015) 21 14376) to generate new probe molecules for chemical proteomics and chemical biology. Dependent upon the particular target these might have applications in the study of protein phosphorylation by chemical proteomics, in general applications for target identification and protein labelling, or enable us to generate highly functionalised proteins in tandem with our sortase-catalysed methdology (Angew. Chem. Int. Ed. (2012) 51 9377). Entry requirements First or Upper Second Class UK Bachelor (Honours) degree or equivalent Subject Area: Inorganic Chemistry, Materials Science Keywords: Chemistry, Inorganic Chemistry, Materials Chemistry