Postdoctoral Research Fellow X 2

Elucidating the molecular mechanisms of DNA Primase-Polymerases Applicants are invited to apply for two postdoctoral positions to study the mechanisms of Primase-Polymerases (Prim-Pols) essential for copying and repairing DNA, which play key roles in genome stability. Many Prim-Pols synthesise primers to initiate DNA replication. Although priming activity was first identified over half a century ago, its synthesis mechanism is still poorly understood. The major aims of this proposal are: Define the molecular mechanism by which Prim-Pols initiate primer synthesis. Elucidate the molecular basis for eukaryotic PrimPol’s primer synthesis activity. Determine the molecular basis for primer extension by Prim-Pols. Characterise the activities and mechanisms of novel Prim-Pol enzymes and define the biological pathways they belong to. Applicants must have extensive experience in using biochemical, crystallographic / CryoEM, and / or biophysical techniques to study the molecular interactions and mechanisms of proteins / complexes involved in DNA / RNA repair, replication, CRISPR, transcription or related cellular processes. Required qualifications for this position: A PhD in biochemistry, structural biology or equivalent A minimum of one recent first author publication in a reputable journal Proven track record working on DNA/ RNA metabolising enzymes Advanced skills in biochemistry, structural biology and /or biophysics Highly motivated to work with protein complexes involved in DNA replication /repair Commitment to work in a highly competitive field. Ability to independently drive a research project and analyse data Fluent in written /spoken English and writing scientific reports/papers. What we offer: A highly motivated and dedicated international team. Innovative projects at the forefront of this research field Excellent collaborative research facilities and environment Collaborations with many labs in our centre and abroad A project where your contribution will make a real impact! These positions may potentially be extended by up to 12 months, depending on the availability of funding. Please contact Prof. Aidan Doherty, Email ajd21@sussex.ac.uk for informal enquiries. Based in the School of Life Sciences, the Genome Damage and Stability Centre  (http://www.sussex.ac.uk/gdsc/), is an internationally renowned Institute carrying out research on the response of cells to DNA damage, genome instability and its relationship to disease. We provide a stimulating and supportive environment and our expertise covers a range of experimental systems. The School of Life Sciences is committed to increasing the diversity of its staff and providing an inclusive working environment. The School currently holds an Athena SWAN Silver Award, has developed a Race Equity Action Plan and hosts an active Equality, Diversity and Inclusion working group. Applications are particularly welcomed from Black and minority ethnic candidates, and women, trans and non-binary candidates, who are under-represented in the School of Life Sciences. Applications to posts from candidates who wish to work part-time or as job-sharers are welcome. The University offers various schemes to provide real benefits to parents, these can be found at Family Friendly Policies Potential candidates are strongly encouraged to make informal contact with Prof. Aidan Doherty [He/Him] before applying. Applications should be accompanied by a full CV, a statement of research interests and aspirations (not more than 1 page), and the names of three academic referees. “Please note that this position may be subject to ATAS clearance if you require visa sponsorship.” For full details and how to apply, click the 'Apply' button above.