Bioconjugation Senior Scientist, Tumour Targeted Delivery, Oncology R&D

Company	AstrazenecaSee more
Address	London, Greater London
Salary	Full-time
Category	Scientific

Job description

This is an exciting opportunity for a laboratory-based scientist to join the Bioconjugation group in Tumour Targeted Delivery (TTD) -Chemistry Site, London, UK. You will become part of a growing team of Bioconjugation scientists and play a pivotal role in the delivery of robust and high-quality data to support drug discovery projects within the Oncology portfolio. Working collaboratively with other disciplines across AstraZeneca you will have the opportunity to contribute to the research and development for early phase projects. You should have a background in Oncology/Biology/Chemical Biology and a strong passion for experimental work and delivering data from the laboratory. You will use your scientific judgement, strong ability to analyse experimental data and use effective communication skills to contribute to decision making for early-stage drug discovery programmes. As a Bioconjugation Scientist, you'll have a deep understanding of the range of analytical procedures relating to bioanalysis/bioscience. You will expertly design and conduct laboratory projects/experiments, develop analytical methods, and generate, interpret, and report scientific data to relevant stakeholder.

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.

Site description

Our TTD-Chemistry site situated in Whitechapel, London is one of over 400 sites here at AstraZeneca, providing an environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you After-work events, Lunch & Learns, spacious balanced office working environment. Situated in the heart of London’s historical east end close to the fashionable areas of Shoreditch, Spitalfields and Brick Lane with excellent public transport links to central London.

Business area

In the Oncology Business Unit we relentlessly follow the science, challenging the norm to deliver more effective treatments to patients in need. Our dedication means we purposefully push back the limits of knowledge to change the practice of medicine. To ensure no patient is left behind, no matter what stage of disease. Fast-paced, it takes agility and responsiveness to stay committed in our pursuit of excellence. We work with focus to seek the unanswered questions – innovating, challenging accepted norms, quick decision-making and taking risks. A place of trust, it’s an opportunity to take accountability, be brave, speak up, step up and redefine Oncology, now and in the future. Be a part of improving lives. This is the time to join the team who is confident that cures for cancer are within our grasp.

What you’ll do

Develop, optimise and scale up drug discovery research lab experiments independently by applying the techniques of Bioconjugation of small molecules to antibodies and related scaffolds
Perform routine interpretation of data with little or no guidance, with a clear understanding of its implications within drug discovery and effectively communicate to relevant stakeholders in a clear and concise manner
Works independently within a team and collaboratively with internal and external stakeholders
Maintains a well-developed understanding of approaches to Targeted Delivery of therapeutics within Oncology
Remain up to date with relevant recent advances and relevant technology including published papers/patents with peers
Authoring and reviewing relevant documents including laboratory notebooks, protocols and reports
Ensures own work, and work of peers, follows Good Laboratory Practice, Safety, Health and Environment standards and all other relevant internal AstraZeneca standards and external regulations

Essential for the role

Ph.D in Chemistry, Biochemistry, Bio/Chemical engineering or relevant discipline
M.Sc or B.Sc in above disciplines with relevant industrial experience
Strong background in chemistry and protein biochemistry
Hands on experience of performing a range of protein/bioconjugate characterisation by UV/Vis spectroscopy, size-exclusion/hydrophobic interaction/ion exchange chromatography HPLC and LCMS
Experience with executing preparative chromatography purifications using AKTA and TFF systems
A track-record of protein/related scaffold modification experience
Knowledge and strong understanding of developing and optimising robust analytical methods for protein/bioconjugate characterisation might be beneficial
Antibody-drug conjugate experience might be beneficial
Biophysical Characterization of protein/related conjugates might be beneficial.

Why AstraZeneca?

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and ignite your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. A culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?