Researcher/Higher Scientific Officer In Replication Dynamics

Location: Clarendon Laboratory/Dorothy Hodgkin Building We are looking to hire an outstanding senior technical staff member (higher Scientific Officer) to support our group’s research, which focuses on studying DNA and chromatin Replication at the single-molecule level. You will form part of the research team core and support the wider group through outstanding technical support and research in molecular biology and biochemistry focused on DNA replication. Understanding DNA replication is important, because during our lifetimes we copy approximately a lightyear’s worth of DNA, and how the different components of the molecular machinery (the replisome) work together to achieve this successfully is an area of highly active research. In our lab, we take on the exciting challenge of understanding the dynamics of DNA replication by studying the activity of eukaryotic replisome at the single-molecule level on both bare DNA and chromatin. Taking on this challenge represents an interdisciplinary team effort that brings together biologists, biophysicists, biochemists, and data scientists within the group.  This research, carried out together with collaborators at the University of Oxford, the Francis Crick Institute, the Hubrecht Institute, and elsewhere, should lead to new discoveries and insights that inform our quantitative understanding of DNA replication and advance this exciting field while contributing to the next generation of in vitro single-molecule methods. Requirements For this innovative, interdisciplinary project, we are looking a biochemist, with: A successfully completed Ph.D. degree in biochemistry or closely related field; Substantial post-doctoral research experience; Practical experience and scientific maturity in the above areas, also as evidenced through your publication record; Strong skills and interest in DNA-protein interactions, DNA replication, and protein biochemistry; Demonstrable experience and skill in protein purification; Ability to independently plan and manage research projects; Ability to contribute to the raising of research  funds; An independent, well-organized, and reliable work style together with an ability and interest to technically and scientifically support the functioning of a research team; Good interpersonal communication skills and a strong interest in the biomolecular sciences, thereby contributing to our interactive lab culture. Information and application For more information about these positions, or to apply, please contact Prof Nynke Dekker, e-mail: nynke.dekker@physics.ox.ac.uk Applications should include a motivated cover letter of application, a detailed CV, and the names and contact information of three references. Applications will be evaluated on a first-come, first-served basis, with the final deadline for applications being 12 noon on June 12th, 2024.