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Salary Job Description
Vertex is currently seeking a highly motivated Research Scientist with a strong background in protein Mass Spectrometry (MS) and proteomics to join our Biological MS team in our Proteins, Cells and Structural Sciences Department in Oxford, UK. This team supports projects from early stage through to preclinical and provides a global capability in state-of-the-art Protein Mass Spectrometry. The position requires a proven track record in the design, preparation, execution and analysis of unbiased proteomics and targeted quantitative protein/peptide assays to interrogate disease biology and enable small molecule drug discovery. In addition, the successful candidate will also contribute to running and analysing small molecule quantitative MS assays. Excellent communication skills are required as is a strong ability to work in a team. Experience with other MS techniques such as small molecule, Native, HDX, or biomolecule characterisation would be considered a plus, as would previous industrial experience.
As a key player within a vibrant and expanding multi-disciplinary drug discovery team you will be exposed to every aspect of drug discovery and development in one of the world’s leading biotechnology companies with an uncompromising commitment to patients and a focus on innovation.
Key responsibilities:
- Design and execute novel quantitative Mass Spectrometry assays for peptides and proteomics.
- Design, develop and optimize methods in chemoproteomics to identify small molecule target engagement.
- Develop and optimize workflows from sample preparation to data acquisition and data analysis, including statistical analysis.
- Routinely support running and analysing established small molecule quantitative MS assays.
- Support running of MS instruments and take responsibility for routine upkeep.
- Deliver results in a fast-paced and dynamic research environment and be willing to learn new techniques and technologies as required by the role.
- Organise, record, and report results according to data integrity guidelines.
- Interpret and explain results to cross-functional teams.
Key Requirements
- Relevant Ph.D. with Mass Spec industry experience.
- Demonstrated track record of method development and application of common proteomics and MS acquisition techniques such as PRM, DDA, TMT, SILAC, etc. is required.
- Experience with quantitative analysis of Mass Spectrometry software such as MaxQuant and Skyline.
- Practical experience working with a variety of MS systems, experience with Thermo orbitrap instruments is necessary.
- Hands-on experience troubleshooting complex instrumentation.
- Expertise with sample prep and Mass Spectrometry method development and optimisation.
- Ability to comfortably manipulate, analyse and interpret complex data.
- Self-driven ability to organize resources and data, manage time and priorities.
- Desire to work in a fast, collaborative, and team-oriented environment.
- The ability to communicate clear and concise updates across a variety of audience levels, keep track of experimental records and results.
- Demonstrated ability to work as part of a multidisciplinary team.
#LI-MS1 #LI-Onsite
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com.
