Translation Research Scientist

Location: The Francis Crick Institute, Midland Road, London Short summary We are looking to recruit an enthusiastic Research Scientist to this translational programme with strong expertise in biochemistry and molecular biology, interested in developing cutting-edge diagnostic technologies for cancer patients with DNA repair deficiencies. The successful candidate for this particular role will be embedded in the laboratory of Stephen West with a focus on cancer biology, investigating critical factors involved in DNA damage repair.    The goal of this project is to advance personalized medicine in oncology, ensuring that patients receive the most effective therapies based on their unique tumour profile, leading to improved patient outcomes and more efficient use of healthcare resources. Our approach is to develop a novel assay platform to assess DNA damage repair pathways. Our patent-pending technology has been supported by outstanding innovation-focused sponsors including the Crick Translation Fund, CRUK Cancer Research Horizons, MedTech SuperConnector, and Cancer Tech Accelerator. Key Responsibilities Support the delivery of the project by undertaking laboratory research, developing the project in a timely and resource efficient manner (design and execute experiments, collect and analyse data) Lead on the optimization of cutting-edge assays to characterize DNA repair mechanisms in various biological models, playing a pivotal role in the assessment of clinical utility. Lead validation efforts to establish assay reliability and accuracy, comparing results with established benchmarks. Design and execute experiments for assay adaptation to scalable formats, contributing to the development of high-throughput capabilities. Develop and refine experimental protocols, ensuring the generation of high-quality data and compliance with industry and regulatory standards. Maintain electronic laboratory notebooks for proper documentation of research activities, ensuring data integrity and reproducibility. Participate in the research community by attending seminars, workshops, and conferences to stay abreast of the latest scientific advances and foster collaborative relationships.  About us The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases. An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London. The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe. The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.  If you are interested in applying for this role, please apply via our website. The closing date for applications is 26/04/2024 All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.