AddressHuman Biological Samples (HBS) are essential for advancing medical research, particularly in developing and implementing new treatments and diagnostics. Due to their ethical sensitivity, HBS form the cornerstone of every clinical trial.
The Biobank Histopathology Scientist will assume a pivotal role in supporting the UK Biobank Lead by establishing capabilities for sectioning, staining, and scanning HBS. Collaboration with internal customers to ensure adherence to global standards and regulations is key to this position.
Furthermore, the role involves identifying opportunities for IT improvements and providing mentorship on the availability and sources of HBS. Proficiency in routine Histopathology techniques and a solid understanding of HBS principles are indispensable for this role.
In this role you will be accountable for maintaining the HBS inventory in adherence to Global Standard, Good Clinical Practice (GCP), and Standard Operating Procedures (SOPs). Emphasis is placed on accurate sample handling, encompassing receipt, logging, storage, tracking, processing, dispatch, return, and disposal. Utilising niche IT systems and databases, the role ensures the sample library's compliance, with daily communication with HBS users and customers as an integral responsibility.
Responsibilities will include:
- Support the daily run of all aspects of histology capability.
- Supply to laboratory maintenance of histology and microtomy areas, relevant SOPs, equipment maintenance, COSHH guidelines and risk assessments. In addition, the role holder will understand SHE procedures and other regulations applicable to the subject area.
- When applicable, provide histological technical support to the organisation, including Microtomy, cryo sectioning, routine histological staining, immunohistochemistry staining, slide scanning and digital image analysis.
- To support the implementation and continued maintenance of archiving of all study-based materials, including raw data, images, FFPE blocks and slides. Ensure that all electronic records are continually maintained and available for audit.
- Maintains an up-to-date knowledge of current sample management and analysis techniques and regulations to support histology/microtomy capability.
- Process shipments/requests for HBS to users.
- Perform all work following global standards, SOPs, GCP and legal requirements – Human Tissue Authority (HTA)
- Communication with science partners to ensure compliance with global HBS standards and legal requirements (HTA).
- Supervise all ongoing projects using niche informatics systems and databases so that there is a common understanding of status at all times.
- Responding to HBS users' queries.
- Act upon day-to-day issues and partner with Biobank groups globally and internal and external customers to drive continuous improvement.
- Knowledge of the transportation of HBS internally and contact with sample dispatch and external couriers.
- Ensure that specialist knowledge is updated to develop greater independence in delivering work.
- To ensure the upkeep of laboratory equipment and cleaning records.
- To assist in the input and tracking of HBS onto local LIMS.
Essential experience:
- Fully proficient in Microtomy and other routine Histological techniques
- Proficient in English as the AstraZeneca working language
- Degree in a scientific field (BSc and/or MSc or equivalent experience)
- Excellent social skills
- Excellent attention to detail and ability to work on prolonged routine tasks
- Ensure all the laboratory components within planning operational delivery documents are accurate and fit for purpose.
- HTA knowledge and understanding
- Understanding of working with various IT solutions
- Experience in carrying out activities promptly and to the correct standards
- Identifying and supporting continuous improvement processes
Desirable experience:
- Experience in Biobanking
- Clinical Laboratory scientific experience
- Experience in the management of projects
- Training management of staff in microtomy areas
Why AstraZeneca?
At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.
So, what’s next?
- Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.
Where can I find out more?
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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
