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SalaryWe have an exciting opportunity in the School of Medicine and Population Health for a Lab Manager/Research Associate position, which is perfect for a researcher with a passion for working in a team to driving biological discoveries through to development of new cancer therapeutics. It is ideally suited to an enthusiastic researcher looking to use their skills in cancer biology, bone biology, cancer cell dormancy, translational research and/or relevant fields who want to have an impact on patients with incurable cancers that grow in bone.
You will join the School of Medicine and Population Health at The University of Sheffield, and become a member of the Cancer and Bone (CAB) Lab, led by Dr Alanna Green. The CAB Lab is within the Division of Clinical Medicine and the University-wide interdisciplinary Cancer Research Network and Mellanby Centre for Musculoskeletal Research. We have a diverse work environment that is world-leading for bone oncology, with a strong history of taking discoveries from the lab through to the clinic. Our team uses innovative models and techniques to investigate the mechanisms that enable cancer cells to evade chemotherapy, including the role of the bone microenvironment. We publish our work in leading journals and conferences in the field, and have taken our discoveries in the lab through to clinical trials. You will be supported with a number of career development opportunities, including attending conferences and training courses.
We are seeking an enthusiastic and organised researcher to work on the first phase of an 8-year Wellcome Trust funded award. The project will investigate how dormancy allows cancer cells to evade chemotherapy and identify weaknesses of dormant cells to enable us to develop new dormancy-targeting therapeutics. You will be responsible for management tasks in the lab, supporting research and will have the option to work on your own project in the team. Management tasks will include: training new staff and students on equipment, preparing stocks, ordering laboratory supplies and ensuring health and safety documentation remains up-to-date. You will use clinically-relevant in vitro (2D/3D) and support mouse models of multiple myeloma dormancy and chemotherapy-resistance developed in our team. You will be based at The University of Sheffield working in a friendly and diverse team, and liaise with international collaborators at the Luxembourg Institute of Health, Karolinska Institute, Sweden, The Garvan Institute, Australia and industrial partners Oxcia AB.
You should have a Bachelor’s degree in a relevant biomedical field (molecular or cell biology, cancer biology, bone biology) or have equivalent experience. You will be a highly motivated, organised and hard-working with the ability to design, perform and analyse experiments with attention to detail and integrity. The project will include a wide range of models and techniques, experience in cell culture is essential, with experience in tissue processing, histology and immunofluorescence microscopy in cancer or bone tissue being desirable. The willingness to support mouse studies is essential, and experience in mouse models of myeloma/cancer and/or bone would be highly desirable. Any experience in techniques that are relevant to the wider project would be appealing: RNA sequencing, metabolomics, bioinformatics, CRISPR-Cas9, flow cytometry, qPCR, western blot and other molecular biology techniques. You will communicate your findings with the group, at scientific meetings and through preparation of scientific publications. Excellent communication skills, written and oral, and the ability to work effectively in a multidisciplinary team, are essential.
This is a 3-year post, with potential to extend to 2032. We are committed to exploring flexible working opportunities which benefit the individual and University.
We’re one of the best not-for-profit organisations to work for in the UK. The University’s Total Reward Package includes a competitive salary, a generous Pension Scheme and annual leave entitlement, as well as access to a range of learning and development courses to support your personal and professional development.
We build teams of people from different heritages and lifestyles from across the world, whose talent and contributions complement each other to greatest effect. We believe diversity in all its forms delivers greater impact through research, teaching and student experience.
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