Senior Bioinformatician: Single Cell Multi-Omits Of Developmental Trajectories

The Ahringer laboratory at the Gurdon Institute in the University of Cambridge is seeking a talented and motivated Bioinformatics research associate to join their research group. Our research aims to decipher the step-by-step genomic regulation that drives developmental programmes. A single-celled totipotent zygote produces a multitude of different cell types, however, the genome regulation that drives development is poorly understood. We address this by combining single-nucleus multi-omic profiling with the known lineage of C. elegans, which enables determination of the locus-specific regulation of chromatin and gene expression across all cell divisions from the zygote to the differentiated state (http://www.ahringer.group.gurdon.cam.ac.uk/). You will investigate genomic regulatory mechanisms in close collaboration with experimental colleagues, using existing cutting-edge software or devising new methods to analyse single-nucleus profiling data as well as other types of genomic and transcriptomic data. You will lead computational projects, participate in research activities of the laboratory as a whole, and contribute to the supervision of students, providing an ideal opportunity to develop an independent scientific career. You will ideally have a strong background in bioinformatics and statistics and prior experience in the analysis single-cell and other types of high-throughput data (e.g., RNA-seq, ATAC-seq, ChIP-seq, CUT&TAG, and chromatin interaction). You should also have a PhD in a relevant subject, a sound understanding of molecular biology, and a strong publication track record in bioinformatics. You will be expected to be able to work independently, interact well in a dynamic multidisciplinary team environment, and be able to communicate ideas and results clearly. The Gurdon Institute is a world-renowned centre of Developmental biology and Cancer research embedded in the University of Cambridge. It provides an exceptional and stimulating environment that promotes collaborative and interdisciplinary research in a supportive and modern setting, with access to state-of-the-art technologies such as super-resolution imaging, single-cell analyses, genome engineering, and genomics and computer modelling. Its postdoc association encourages scientific and social interactions and also provides career development and teaching opportunities. The post is initially available for 2 years, with the possibility of extension subject to available funding.  Please ensure that you upload your Curriculum Vitae (CV) and covering letter in the Upload section of the online application. If you have any questions about this vacancy or the application process, please contact hr@gurdon.cam.ac.uk.  If you would like to know more about the role and projects, please contact Prof. Julie Ahringer ja219@cam.ac.uk. To apply online for this vacancy and to view further information about the role, please click on the apply button above. Please quote reference PR40053 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK.