Job description
Fixed term – Starting ASAP – until July 2026 Full-time, 35 hours per week 2 positions This exciting industry academic collaboration aims to develop a suite of genetic tools for Engineering Biology applications in CHO cell biologics production. The opportunity: Engineering Biology for Biologic Drug Production Biologic drugs are a rapidly expanding area of the pharma industry and the market is expected to reach over $620B in the next 10 years so there is huge future potential for scientists skilled in this area.CHO cells are the most widely used industrial system for producing recombinant therapeutic proteins, but can struggle to express some protein-based therapeutics at high quality and sustained high levels. We will address these issues with a systematic programme of Engineering Biology and genome engineering that combines innovative approaches to concomitantly increase CHO cells' capacities to express and secrete important industrially relevant biologics. The research will take full advantage of state of the art facilities including the Edinburgh Genome Foundry (www.ed.ac.uk/biology/research/facilities/edinburgh-genome-foundry). There will be multiple opportunities to interact with leading academics and our industrial partners Fujifilm Diosynth Biotechnologies. The post works with the Chair of Synthetic Biology and Lead Applicant Prof Susan Rosser and is responsible for the planning, coordination, implementation, execution, and project managing of the project goals. This project is part of an £8.7M EPSRC Prosperity Partnership between Fujifilm Diosynth Biotechnologies UK and the Universities of Edinburgh, Manchester and York (www.ed.ac.uk/biology/news-events/news-2021/8-7m-collaboration-modern-medicines). There will be multiple opportunities for the post holder to interact with leading academics and industrial partners. Applicants should have or shortly obtain a PhD in an appropriate discipline with research experience in at least one of the following: CHO cell biologics/protein production, synthetic biology, genome editing/engineering, mammalian cell engineering, molecular biology or a related area. Experience in bioinformatics is highly desirable. You must have excellent verbal and written communication skills and be able to write clearly and succinctly for publication. You must also be able to develop and apply new concepts and have a creative approach to problem-solving. The successful candidates will join the lab of Prof Susan Rosser (rosser.bio.ed.ac.uk). Prof Rosser is the director of the BBSRC/EPSRC/MRC UK Centre for Mammalian Synthetic Biology (CMSB) (www.synbio.ed.ac.uk) and co-director of the Edinburgh Genome Foundry (www.genomefoundry.org), hosted by the School of Biological Sciences at the University of Edinburgh. Find out more about our Engineering Biology community here: www.ed.ac.uk/biology/centre-engineering-biology Your skills and attributes for success: CHO Cell engineering Genome Editing Mammalian Synthetic Biology Bioinformatics
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City of Edinburgh, Scotland
