Research Fellow In Childhood Leukaemia

About us The mission of the UCL Great Ormond Street Institute of Child Health is to improve the health and well-being of children, and the adults they will become, through world-class research, education and public engagement. The UCL GOS ICH, together with its clinical partner Great Ormond Street Hospital for Children, forms the largest concentration of children’s health research outside North America. GOS ICH’s activities include active engagement with children and families, to ensure that our work is relevant and appropriate to their needs. GOS ICH generates the funding for our research by setting out our proposals in high quality applications to public, charitable and industrial funding bodies and disseminates the results of our research by publication in the medical and scientific literature, to clinicians, policy makers and the wider public. The Institute offers world-class education and training across a wide range of teaching and life learning programmes whic! h address the needs of students and professional groups who are interested in and undertaking work relevant to child health. About the role We would expect the candidate to work within the Leukaemia Biology team headed by Professor Marc Mansour, and collaborate closely with Dr Paul Maciocia’s group at the UCL Cancer Institute. The Leukaemia Biology group sits across the UCL GOS Institute of Child Health (ICH) and UCL Cancer Institute, with the post administered and based through ICH. The project will involve a wide range of techniques including molecular biology, cell culture, antibody development and in vivo work in mice. The aim of the project is to develop and test therapeutic antibodies against CCR9 in vitro and in vivo in a humanised mouse model. Ultimately, we hope to use these data to take the best antibody candidate forward to a clinical trial. The salary offered on this role is £42,099 - £43,205 per annum and is funded until 30/09/2026 in the first instance. About you The successful candidate will have a PhD in a relevant scientific area, a strong academic track record and be highly enthusiastic about science. The candidate will be expected to have excellent skills in molecular biology and cloning, be proficient in cell culture and FACS, and have experience with handling mice. Experience with the development and administration of therapeutic antibodies is desirable, but not essential. An ability to work constructively within a team, including supervising research technicians and students, is essential.