Address
Form of work
SalaryGrade UE07 - £37,099 - £44,263 per annum (A revised salary range for this grade of £39,347 - £46,974 is planned to take effect from Spring 2024).
College of Science & Engineering - School of Biological Sciences, Institute of Cell Biology
Full time – 35 hours per week
Fixed Term 12 months
The Opportunity:
Applications are invited Postdoctoral Research Associate in the laboratory of Prof. Julie Welburn, funded by BBSRC for up to 36 months. The laboratory investigates fundamental mechanisms of the microtubule cytoskeleton in cell organization in different cell types, and in cell division and disease at the molecular and cellular level. In human cells, there are multiple a-tubulin isotypes and b-tubulin isotypes distributed in different cell types. Many pathogenic tubulin mutations are dominant negative and associated with tubulinopathies and cancer, yet the pathogenic mechanism is unclear.
The project will involve using cell biology and biochemical and structural approaches to 1) understand how the isotype-composition and properties of microtubule tracks control motor-cargo complexes and cellular architecture to modulate cell function and properties 2) discover the mechanism underlying pathogenic tubulin mutations.
We are now looking for an enthusiastic and talented researcher to join our team investigating the molecular diversity and function of tubulin isotypes and the mechanisms that underlie tubulin-isotype-specific diseases. You will play a major role in the design and conduct of the research project and be trained in the relevant techniques. You should have, or will shortly obtain, a PhD in a relevant subject area and will have experience in structural biology and biochemistry or/and advanced imaging and image analysis. Training can also be offered. An outstanding academic track record is essential and at least one first author publication in a prominent journal is expected.
Your skills and attributes for success:
Must hold (or close to complete) a PhD in biochemistry, structural biology, cell biology or related discipline
Work independently and have experience in general lab techniques including protein purification, cloning, cell culture and imaging
It would be desirable to have experience in structure determination although training can be provided
