AddressPosted Date: Mar 13 2024
GSK is looking for exceptional Spatial Biology scientists to develop multiplex spatial immuno-assays, to be based in the Bioimaging group at our R&D site in Stevenage, UK.
This exciting role provides a rare opportunity for the applicant to develop highly desirable skill sets in spatial multiplex assays. The role requires advanced histology, imaging and data analysis expertise, which the successful candidate will combine in order to design and implement novel multiplexed spatial biology assays, aiming to provide molecular phenotyping of tissues with spatial context.
In particular, the role will be focused on using cutting edge technologies that bridge imaging and omics domains to enable high-resolution, highly multiplexed localization and quantitation of targeted RNA and protein panels at single cell level or better. The data delivered by these assays will contribute to key decision-making points in projects across GSK’s portfolio from target validation to late-stage assets.
The role will additionally involve providing expert scientific input to colleagues in related imaging and genomics teams to achieve the best experimental designs for proposed projects and maximize the delivery of decision-making data obtained from critical samples, accelerating the path to effective and safe drugs that help patients to do more, feel better, and live longer.
Depending on the experience of the successful candidate, the role may be offered as a Senior Scientist or Investigator position.
Bioimaging at GSK
At our world class scientific hub in Hertfordshire, UK, our Bioimaging department brings together key areas of in-vivo and ex-vivo imaging combined with histology to understand both disease state and interventional drugs, combining data on drug distribution with the effect that the drug has on intact biological systems.
As well as using existing modalities we keep aware of developing technologies and analytics through an extensive internal and external network. We work closely with other Bioimaging teams, making use of expert resources available across R&D including pathologists, AI scientists, data analysts and biology specialists.
This role will provide key capabilities to the team, combining the precision of probe-based assays, the context of imaging and the scale of omics technologies to provide powerful statistically robust insights into biological processes and the effect of interventional drugs.
We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.
We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.
Discover more about our company wide benefits and life at GSK on our webpage Life at GSK | GSK
In this role you will
- Deliver defined multi-modal spatial multiplexing project packages and contribute to broader packages of work in support of project teams, from conception through to data interpretation and delivery.
- Contribute technical, scientific microscopy and multi omics spatial multiplexing expertise to experimental design, lab work, computational analysis (image analysis, data analysis), and scientific interpretation of data generated, including comprehensive and timely documentation.
- Develop new methods and study designs that will provide earlier, more rapid and more clinically relevant spatial multiplexing data to improve overall project quality and reduce drug development timelines.
- Write and issue/ submit reports (company reports and scientific publications) on results obtained if required.
- Perform sample preparation and routine data acquisition procedures as appropriate. Be willing to provide hands-on lab work and technical / scientific expertise in other areas of the department/division, if required, when not engaged on priority projects in primary discipline.
- Make scientific oral and poster presentations at internal project meetings, symposia, departmental meetings, and external conferences, and contribute to the strategy of the department.
Why you?
Basic Qualifications & Skills:
We are looking for professionals with these required skills to achieve our goals:
- Bachelor’s or Master’s degree with demonstrated role performance equivalent to a PhD or postdoc in Immunoassay, Imaging, Transcriptomics/Proteomics or related field.
- Proven ability to work in a proactive and agile way in the laboratory to conceive, design, execute and interpret immunofluorescence, in situ hybridisation and in situ sequencing assays using established and novel methods.
- Handling, processing and fixation (including freezing) of a variety of tissue types to ensure highest sample quality. Preparation of high-quality paraffin and cryosections.
- Deep understanding of fluorescence-based tissue-slide assay technologies and experience in generating decision-making data using these technologies.
- Understanding of the requirement for reagent and assay validation and experience in delivering high quality assays using automated staining and imaging platforms.
- Experience in using software applications for image analysis, data analysis/ visualization and data interpretation of images from tissue samples, including AI / machine learning algorithms.
Preferred Qualifications & Skills:
Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:
- A track record of research in immunology, oncology, or neuroscience.
- Experience with one or more modern spatial biology technologies including but not limited to: In situ hybridisation (RNAscope /FL/HiPlex assay or similar), fluorescence cyclic Imaging technologies (Leica Cell Dive, Lunaphore COMET or similar), Spatial transcriptomics (10X Xenium/ Visium or similar), widefield brightfield and fluorescence imaging automation, confocal microscopy.
- Strong publication record
- Broad experience and in-depth knowledge of molecular biology techniques, molecular characterization at genomic, RNA, and protein levels (genomic PCR, RT-PCR, Western), including the benefits/ pitfalls of each approach.
- Ability to work with scientific computer code e.g. Python, R, xml.
- Cell culture experience (cell lines and primary cells)
Closing Date for Applications – Tuesday 2nd April 2024 (COB)
Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
Why Us?
GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organization where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to positively impact the health of 2.5 billion people by the end of 2030.
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We’re committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.
As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).
We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on Ukdiversity.recruitment@gsk.com or 0808 234 4391.
Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the link and scroll to the Careers Section where you will find answers to multiple questions we receive
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