Research Fellow (108358-0124)

Warwick Medical School (WMS) at the University of Warwick wishes to appoint a Research Fellow to develop statistical methods for analysing adaptive platform trials. The exciting project is funded by MRC-NIHR Better Methods for Better Research Programme for 3 years. Salary will be within the range £33,966 - £44,263 per annum, depending on qualifications and experience, plus a market supplement of £5,000 per annum. You will develop methods to analyse adaptative platform trials whilst addressing statistical challenges the analysis pose. Platform trials are multi-arm, that is, multiple experimental treatments are tested, and are multi-stage, that is, multiple interim analyses are performed to adapt the trial based on accrued evidence. Therefore, there is a challenge to adjust analysis for multiplicity arising from multiple treatments and multiple interim analyses. New experimental treatments may also be added partway through a platform trial. This poses additional challenge of whether, whilst comparing an added treatment to the control treatment, patients randomised to the control treatment before adding the treatment should be included, and if so, how. Other challenges include the fact that the standard of care and hence control treatment may change during the trial. Analytic and simulations techniques will be used. You will work with Principal Investigator Dr Peter Kimani based in Warwick Clinical Trials Unit (WCTU) in WMS, Prof Nigel Stallard, Professor of Medical statistics and Director of WCTU, Prof Keith Abrams, Professor of Statistics & Data Science in the Department of Statistics in the University of Warwick, Prof Andrew Metcalfe, an orthopaedic surgeon and a Professor of Clinical Trials in WCTU and Prof Jeremy Chataway, a consultant neurologist and Co-Programme Lead for Neurodegenerative Diseases at the UCL MRC Trials Unit. To support you develop a long-term research programme, you will be encouraged, in collaboration with colleagues in WCTU and wider WMS and university, to lead or contribute to grant applications to generate further funding. The post is primarily research, but there will be opportunities for teaching and assisting in the supervision of postgraduate students. Full details of the duties and selection criteria for this role can be found in the vacancy advert on the University of Warwick's jobs pages. You will be routed to this when you click on the Apply button.